Metrabase

Metabolism and Transport Database

Results

1 hit

  telmisartan
MBID: mbcd0004705
CSID: 59391
CCCC1=NC2=C(C)C=C(C=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C(O)=O)C1=NC2=CC=CC=C2N1C
InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChIKey=RMMXLENWKUUMAY-UHFFFAOYSA-N
Molecular mass: 514.62
Calc. log P: 6.04; calc. log D (pH 7.4): 5.02
MDR1 non-inducer Abstract PMID: 20222053 DOI: 10.1002/bdd.699
BCRP1 inhibitor Abstract PMID: 20222053 DOI: 10.1002/bdd.699
non-inducer Abstract PMID: 20222053 DOI: 10.1002/bdd.699
MRP2 inhibitor Abstract PMID: 20222053 DOI: 10.1002/bdd.699
non-inducer Abstract PMID: 20222053 DOI: 10.1002/bdd.699
MCT1 non-substrate Abstract PMID: 16327156 DOI: 10.1248/bpb.28.2235
OATP1B1 inhibitor Abstract PMID: 16595711 DOI: 10.1124/dmd.106.009290
Abstract PMID: 22541068 DOI: 10.1021/jm300212s
non-substrate Abstract PMID: 16611857 DOI: 10.1124/dmd.105.009175
OATP1B3 inhibitor Abstract PMID: 22541068 DOI: 10.1021/jm300212s
substrate Abstract PMID: 16611857 DOI: 10.1124/dmd.105.009175
OATP2B1 inhibitor Abstract PMID: 22541068 DOI: 10.1021/jm300212s
substrate Abstract PMID: 16611857 DOI: 10.1124/dmd.105.009175